| 세션명 | Graduate Student Oral Session (I) (English) |
|---|---|
| 발표장 | 제9회장 |
| 논문코드 | 1O9-2 |
| 발표일 | 2021-10-21 |
| 발표시간 | 14:15-14:30 |
| 논문제목 | Fast-curable tissue adhesives for corneal wound healing |
| 발표자 | 이혜선 |
| 발표자 소속 | 부산대학교 |
| 저자 | 이혜선, 양승윤†, Ajeesh Chandrasekharan, 성금용, 조연지1, 이종수1 |
| 소속 | 부산대학교; 1부산대학교 병원 |
| 논문초록 | As a promising alternative of conventional sutures, glue-type tissue adhesives for wound closure is gaining popularity. However, difficulty in controlling adhesion time and poor wet adhesion of existing tissue adhesives limit their practical use in the clinic. Herein, we report in situ hydrogel-forming tissue glues based on photocrosslinkable hyaluronic acid (HA), providing firm tissue adhesion under wet and dynamic conditions. Depending on the degree of photocrosslinkable groups in HA polymer chains, mechanical properties and adhesive performance were improved. In the rabbit corneal incision model, the HA glue quickly sealed the incision site following low-energy UV exposure for 5 seconds and showed uniform corneal wound healing compared to control groups. Considering high biocompatibility and drug-loading capacity of HA hydrogels, the fast-curable HA glue can be applied for diverse biomedical applications, requiring long-term tissue adhesion and sustained drug delivery. |
THE POLYMER SOCIETY OF KOREA